Further marker studies and refined selection criteria are necessary for more specific in vitro CSC isolation.
Further experiments using more refined selection criteria such as a combination of two or multiple markers would be useful to specifically identify and purify CSC.
I paid $1,000 for a three-month membership, during which the service was to set up dates from its database, take feedback from each person after the fact and use it to refine selections for subsequent rendezvous.
Current and emerging markers must be incorporated prospectively into the design of clinical trials that test novel and established agents to better understand their clinical utility and to refine selection parameters and marker interactions.
Future appropriately designed randomized controlled trials (RCTs) to refine selection of patients for medical and surgical treatments should be conducted.
Perhaps the most frequent one is to refine selection criteria to exclude patients unlikely to respond: those with right bundle branch block, severe kidney insufficiency, and high burden of scar.
In particular, absolute risk scores could be used both to motivate individuals to reduce their LC risk through behaviour and lifestyle modifications and to refine selection of participants for LC screening trials on the basis of maximising benefit (Vickers et al, 2006; Duffy et al, 2009).
Feeling less of a social pariah than I expected, I clicked 'interest on a couple of profiles – those I had refined in selection down to a pinprick – and we played a silly game of 'who will message first?' before I gave in.
To control for these differences, we further refined our selection of control patients using propensity score matching.
The inclusion of more amino acids to a proto-code can increases the ATP yield, especially if refined by selection.
We then crosschecked and refined our selection of genes without an expressed Y copy by performing variant calling on two male individuals for which we obtained whole-genome sequence data (supplementary material S1, Supplementary Material online).
