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The refined molecular replacement solution clearly revealed the presence of the bound Aplip1-PxxP1 peptine in 2m Fo − D Fc and m Fo − D Fc electron density maps.
Instead, these measures incentivize consumers to demand, and industry to design, products with lower amounts of fat/calories (usually with refined carbohydrates as replacements).
The structure was solved by molecular replacement, and refined to Rwork/free of 0.22/0.25, respectively (Table 1) with one monomeric PLK4-PB3/STIL-CC per asymmetric unit.
On the basis of the refined complex structure, the replacement of O1 with an aldehyde or methyl hydroxyl would allow for hydrogen bonds with the side chain of R80 while simultaneously maintaining the hydrogen bonds between O2 and O3 and the backbone of the GYGF loop.
Replace refined sugar with healthier sugar alternatives.
Replace refined white flour with healthier alternatives.
Replace refined sugars with natural ones.
84, 85 Severe caloric restriction for 8 weeks with a diet of refined-liquid meal-replacement formula supplemented with some vegetables (510 kcal Optifast with vegetables to a total of 600 kcal per day) was reported to normalize beta-cell function and insulin sensitivity in a small group of type II diabetics (<4 years from diagnosis).
The structure of hMAT1A was subsequently solved by molecular replacement with the refined MAT2A structure.
The long-wavelength dataset was phased by molecular replacement with the refined P212121 model using phenix.phaser.phaser
The BARD1 BRCT repeat structure was solved using molecular replacement methods and refined to 2.1 Å resolution (see Materials and Methods).
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