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Use of the refined profile allowed us to classify the previously built metagenomic database, consisting of 147 non-redundant sequences.
Use of the refined profile allowed us to classify UniProt HisA and PriA sequences, from which 58 selected non-redundant sequences were retrieved.
Once our HMM refined profile was validated using UniProt, it was used to search for promiscuous evolutionary intermediates in the large and diverse metagenomic database CAMERA.
Iterative searches and addition of new positives led to a progressively refined profile with repeats from Tetraodon nigroviridis, Takifugu rubripes, and chicken, which matched mammalian periostin sequences (including human) at E-value 1.8 (3rd iteration).
The profiling explores the multi-criteria ratings in order to obtain the most refined profile.
To improve the HMM profile, a refined profile, constructed from profile 6, was obtained.
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Bias correction refines profiles of average cutting.
We based our choices on our work with states over the past decade to refine profiles of their nursing facility populations for use in policy decisions; we also relied on our previous research and clinical insight.
As a consequence, from a certain quantity of queries in a user profile, refining this profile does not significantly help the adversary to de-anonymize a higher number of queries.
We have not iteratively refined the profile models of individual genes using consensus models from clusters of biologically related genes as previously done [26], [27], [28].
We began with an initial set of seed profiles chosen to cover the space of possible PFM columns and then iteratively refined those profiles.
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