The nearest gene to this association signal is forkhead box protein P1 (FOXP1), which encodes a transcription factor regulating esophagus development and acts as therapeutic target in cancer 4, 5. Furthermore, the BEACON study refined a previously reported association with Barrett's esophagus 6 near the transcription factor forkhead box F1 (FOXF1) gene on chromosome 16q24.
To refine a previously reported linkage peak for endometriosis on chromosome 10q26, and conduct follow-up analyses and a fine-mapping association study across the region to identify new candidate genes for endometriosis.
Our objective was to refine our previously reported subphenotype [7], now limited to patients with sickle cell anemia, and to validate the findings in a larger independent population.
The distances between donor and acceptor were calculated and used as distance parameters to assess and refine the previously reported 3D model of the pRNA dimer.
To refine the association of the previously reported and newly identified disease loci, we imputed untyped genotypes using Impute2 (83), Mach1 (84, 85) or minimac (86) software and HapMap Phase II, Phase III and/or 1000 Genome Project data release 2010-08 or 2010-06 reference genotypes (Supplementary Material, Table S6).
The present work further ascertained previously reported haplogroups, and refined the phylogenetic tree of South Asia.
In conclusion, we have demonstrated the importance of genotyping and imputation-based fine-mapping through the discovery of 12 additional independent PrCa associations within known GWAS regions and by refining the vast majority of the previously reported signals.
New research does not confirm this hypothesis, however, and suggests possible ways to refine our understanding of the association previously reported with DDE [ EHP 116:179–183; Cupul-Uicab et al.].
We have refined the genomic position of known rearrangements previously reported by cytogenetic approaches and described new putative micro-rearrangements (inversions and indels) between human and macaque genomes.
Using two different algorithms, we refined the genomic position of known rearrangements previously reported by cytogenetic approaches and described new putative micro-rearrangements (inversions and indels) in both genomes.
