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Generally, refined means elegant and cultured in appearance, manner or taste, or with impurities removed.
This could contribute to a more refined means of predicting human systemic exposure and any adverse events such as drug drug interactions or tissue-specific toxicities arising from the species-specific disposition of the drug molecule and/or its metabolites.
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Yin et al. employed a two-step approach for fully automated and robust prostate segmentation: first, the prostate region is detected based on the cross correlation of normalized gradient fields; second, a prostate mean shape model is refined by means of a graph-search framework [ 46].
But Mexico's political parties have been tweaking the system for some 13 years now, and even as they've made it more and more complicated, they've refined their means of cheating it.
He insists that D-Day could have been a rout but for the fact that by mid-1944, British, American and Canadian warriors — from the top down — had transformed their organization into a smoothly functioning apparatus, refined their means of gathering intelligence and designed the now-famous "bodyguard of lies" that misled the Nazis about when and how the Allies would invade Europe.
An initial estimate is required which is refined by means of energy minimization.
These solutions are then filtered and refined by means of the PSS instance when answering one specific PSS demand.
Using a single correspondence an initial estimation of the Euclidean transformation is computed and later refined by means of a multiresolution approach.
In our image segmentation pipeline, we use FCNs to obtain normalized images, which are then iteratively refined by means of a FC-ResNet to generate a segmentation prediction.
When a client needs a map to be refined (by means of a gradual content zoom operation), only the 'missing' data will be requested.
The model was originally developed for educational purposes and has been tested and refined by means of field projects; two of them are presented as case studies in the paper.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com