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These databases provide specific metabolic roles for genes acting as a highly refined function prediction.
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We expected that by parsing genes based on coexpression similarities, more refined functions would be condensed within modules, revealing enrichments for more specific processes.
The ability to distinguish between orthology supported by all domains and orthology supported by a subset of the domains only would be helpful to improve the quality of ortholog assignments and refine function inference across orthologs.
The high degree of conservation between human and chimp POP2 suggests that POP2 refined these functions at some point following the divergence of macaques with purifying selection acting at that point to completely conserve POP2 prior to the divergence of humans and chimps (~ 6 mya).
To refine UGT73C6 function in the context of functional redundancy it was therefore aimed to generate plants deficient in the expression of both UGT73C6 and UGT73C5.
In practice, this principle led us to redefine the importance of a residue in terms of the importance of its epistatic interactions with neighbors, yielding better annotation of functional residues, motivating experimental validation of a novel functional site in LexA and refining protein function prediction.
Therefore we assume that the likely SPL7-interactome consists of largely functionally redundant components that probably contribute more to refine SPL7 function, rather than to its activation.
It is not difficult to see how gradual changes (i.e., direct adaptive evolution) could refine the function of lenses once they appeared in very rudimentary form.
As shown in this study, those modules can then be tested experimentally to further investigate and refine the function of the miRNA in the regulatory network.
Protein-protein interactions could also constitute a post-translational mechanism to refine SPL7 function.
CAMBer is supreme in refining gene function prediction according to multi-gene family information, but it does not provide tools for comparative or evolutionary analysis among strains and isolates.
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CEO of Professional Science Editing for Scientists @ prosciediting.com