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Accordingly, the Ussing chamber technique has been refined for the study of small specimens obtained during endoscopy using capsule systems or large size biopsy forceps [ 9, 12- 16].
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The PROSAIC system was chosen: (1) as it had been successfully used previously to solve similar problems of classifying acute general practice presentations from clinical narrative; and (2) as the research team had expertise with this software; and also, (3) because it had been developed by the local PHO involved in the research, it was able to be further developed and refined for this study.
All known methods were not able to specifically produce incomplete burst fractures, and thus needed to be refined for this study.
We developed a data extraction instrument based on checklists used in previous systematic reviews [ 1, 13- 15] but refined for the specific aims of this study.
A good future is seen for further development of refined techniques for the study of electrochemical processes by various combinations of spectroscopic and electrochemical means.
Furthermore, pilots were performed in each setting for refining the study tools and for anticipating potential problems during the field phase.
ABS, JEF and SS were responsible for refining the study design and will be responsible for co-ordinating the acquisition of study data.
The approach was refined to allow for the study of critical materials (Busch et al. 2014), but it has not yet been applied to potentially critical metals on the global scale.
NN critically revised the manuscript, refined the study report, and provided ideas for discussion.
The questionnaires will be refined for further use in a larger study.
The need for large samples to refine the study of effects of modest magnitude and the necessity to replicate studies across different ethnic backgrounds rely on easy access to a large variety of data organized in a systematic way.
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