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We can expect refined classifications of criterion-based diseases such as RA to lead to the use of genetics to provide an indication of what molecular pathways are involved in the pathogenesis of different subsets of today's criterion-based diseases.
Over the past decade, as magnetic resonance imaging has refined classifications of disc degeneration [ 5, 92], it has become evident that, although factors such as occupation, psychosocial factors, benefit payments and environment are linked to disabling back pain [ 93, 94], contrary to previous assumptions these factors have little influence on the pattern of disc degeneration itself [ 95, 96].
There, the only acceptable attitude is to seek finer and more refined classifications of observed reality so as to advance our understanding.
Future studies should develop more refined classifications based on a combination of over-sampling of these travel modes and using related supplemental GIS data (e.g., trails and bus and train routes).
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The resulting phylogenetic tree agrees very well with the recently refined classification of the major fungal lineages (Fig. 3).
As a consequence, refined classification of transcription factors based on nuclear stoichiometric abundance, association-dissociation kinetics, co-regulating partners, and the type of DNA they are bound to (methylated, condensed) will emerge and will challenge the existing classification [ 52, 53].
We did not test whether the performance of the rule-based model would be improved if we refined classification rules using statistics from the UCI data because these data were limited to only three subjects who were indoors 87% of the time and had non-representative outdoor walking data.
Active learning can also be conducted to refine classification labels assigned to each sentence in the corpus.
Given the (i) multi-domain nature of many protein kinases, (ii) difficulty of domain assignment, and (iii) existence of domain shuffling, we wished to propose a protocol to refine classification that would: take into account full-length sequences, be insensitive to domain detection inaccuracies by avoiding the step of domain detection, take into account domain shuffling.
Full sequencing of breast cancer genomes could potentially refine classification and give a more complete picture of the mutational profile of cancer and thus aid therapy decisions.
Finally, we suggest that classical taxonomy and modern genetic approaches must work in tandem, not only to improve the accuracy of species identification but also to potentially refine classifications at the levels of organism, population and genotype in the field and laboratory.
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CEO of Professional Science Editing for Scientists @ prosciediting.com