As each of the multidisciplinary components is refined the challenge is to identify the optimum inclusion and scheduling such that best tumour outcome is combined with lowest treatment toxicity.
The skeptic, however, might refine the challenge as follows: "It's not," she might say, "that I insist on sticking to my intuitions, empirical science be damned.
In terms of the future, professionals have told us that "refining, challenging and stretching creative early years skills and knowledge to a higher level" is a key priority if we want to build and sustain cultures of creativity in our organisations, closely followed by "raising awareness of how and why creative approaches can develop specific areas of early learning".
All of the exhibits were made in the last five years, at a time when digital art and design have become more aesthetically refined and intellectually challenging.
The promising direction is the utilization of the CBMs as frameworks of current knowledge, which can then be challenged, refined and constrained by various high-throughput datasets as discussed in the following section.
The analysis of large-scale vortices from highly refined unsteady simulations becomes challenging as the mesh resolution increases.
It certainly represents big "S cience, having been challenged and refined over the course of the past 40 years through the efforts of tens of thousands of physicists.
Thus, even though this does not comprise a systematic review of all existing literature (which would go beyond the scope of a single publication), we refined the list of challenges until we felt comfortable that all influential topics were covered in the discussion and provided a solid basis to initiate further discussions.
Since the dawn of the space age in the 1950s and the discovery of extrasolar planets in the 1990s, the model has been both challenged and refined to account for new observations.
44 Therefore, it is possible that the results regarding the exact distribution of the receptor in anatomical substructures are likely to be challenged and refined over the coming years.
The evidence on which this scientific fact is based will be refined further, but the next challenge for scientists is broader.
