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These results were achieved by performing a more refined approximation that is valid under quasi-longitudinal (QL) propagation conditions.
As modular interactions are inherently epistatic, we demonstrate that our refined approximation provides insight into the underlying structure of these non-trivial fitness landscapes.
Here we extend this existing picture using a refined approximation, provide a more general analytical formula, and show that in principle up to N(N + 1) / 2 segments can show up experimentally.
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To reduce the uncertainty in the AA and achieve efficient and accurate range analysis of multiplication, this paper presents a novel refined affine approximation method, Approximation Affine based on Space Extreme Estimation (AASEE).
Moreover, in future developments of MaBoSS, we plan to introduce methods for sensitivity analyses, refine approximation methods used in BKMC, and generalize Markov property.
A developable surface approximation procedure is employed to refine incident approximation planes of data points into developable strips.
Since the RMA model only serves as a low-dimensional illustration of the ideas behind the proposal estimation algorithm, we will not refine the approximation further, but rather turn to a high-dimensional example.
The solution technique approximates mean conditions, and solves the deterministic model to refine the approximation, and eventually converge on a solution.
Sequences of two steps could then be used to refine this approximation by adding a second term to the model, and so on.
When the rates of genetic switches are relatively slow but not extremely slow, we can refine the approximation (Eq. 6) by taking into account the transition path information.
In addition, this study refined a basic approximation for targeting nerves of the inferior knee developed by Le Correller et al. and validated the new method with a larger sample of cadaver specimens (15 fresh versus 5 embalmed cadavers) than were used by Le Correller et al. (Le Corroller et al. 2011).
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