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The reported genomic signature identified and further refined the alterations reported by Lu and colleagues [ 41].
Finally, the assembled haplotypes are further greedily refined by testing if sequential alterations of the bases lead to any improvement of the MEC scores, which has complexity O(2 n).
Finally, the assembled haplotypes are further greedily refined by testing if sequential alterations of the bases lead to any improvement of the MEC scores, which has complexity O(K n).
This solution is further refined by greedily exploring whether sequential alterations of the bases along the haplotype sequences might lead to even lower MEC scores.
Moreover, search mechanisms are frequently refined and re-tuned, and even a simple low-level change such as alteration to the parsing mechanism can lead to drastic changes in document ordering.
Varying PQQ in highly refined diets also causes modulation in hepatic mitochondrial content and alteration in mitochondrial-related amino acid and lipid metabolism [ 1, 2, 20, 21].
This seminal description has been extensively refined and expanded, to include epithelial loss of anchorage dependence with the basal membrane, followed by fundamental alterations in genomic and epigenomic program execution in cellular polarity and motility [21],[21].
Minor alterations to the instrument were made based on patient feedback and the interview guide was refined for clarity.
Very refined.
So refined.
"Shanghai is more refined.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com