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Intensified research and surveillance in this area will help determine and refine thresholds for public health interventions.
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These results refine threshold conditions given by previous metapopulation models.
Carefully refining thresholds to ensure that the bargaining parties represent a majority of employers and employees in the industry would be a more thorough-going means of reducing the costs of these ordinances.
rNIRS scores <65% show a high sensitivity, and relative rNIRS values <25% have acceptable specificity, both of which may be improved by refining thresholds in larger patient cohorts.
Note that the two predicted uncertainty profiles bracket 0.5 at the refined threshold.
The chance of a positive prediction being a misclassification is much higher, exceeding 80% near the refined threshold and nearing 90% for the naïve threshold.
(B) Calculated uncertainty profiles and distributions of training pool error rates for model CYP2D6-1a (naïvotinging threshold at 16.5; red), and for model CYP2D6-1b (refined threshold at 27.5; green).
(D) Calculated uncertainty profiles and distributions of observed validation set error rates for model CYP2D6-1a (naïvotinging threshold at 16.5; red), and errors for model CYP2D6-1b (refined threshold at 27.5; green).
This is in contrast to model logP3-3b (indicated by green lines in Figure 10), which uses the same network outputs but a refined threshold and provides more appropriate uncertainty estimates.
To evaluate local practice and refine CK thresholds for the instigation of renoprotective treatment, we studied the correlation between CK time trends and adverse outcomes such as acute kidney injury (AKI), the need for emergency renal replacement therapy (RRT) and mortality.
To further refine these thresholds we obtained estimates of probe noise levels for each of the arrays as described in Fridlyand and colleagues [ 27] to subsequently categorise the arrays by their noise levels with the discriminators being the lower and upper quartiles of the distribution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com