Further innovations have included using multiple discontiguous seeds and refining the patterns of the seeds [ 11, 12].
Drosophila deletion mutants show a sporadic loss of sensory bristles, revealing the role of this miRNA in ensuring the developmental 'robustness' of patterning processes (for example by protecting interommatidial bristles during the programmed cell death that refines the pattern of the pupal retina).
Together, these studies identify an important role for the transcriptional circuit in refining the pattern of gene expression in the neural tube, but it leaves unresolved the question of how different levels and durations of Shh signaling control appropriate gene expression in responding cells.
Furthermore, despite the proselytising tone of A Pattern Language, its introductory discussion states that it was published as a work in progress and encourages readers to continue to refine the patterns contained therein and develop their own new patterns.
The model from Manceau and coworkers [70] was used to refine the patterns.
Several buffer layers of non-superconducting material are deposited on top to refine the pattern.
This Notch activity drives the expression of the Notch target genes E spl), Wingless, and Cut, which together refine the expression patterns of Notch ligands and regulate the spatial pattern of Notch activation in subsequent stages (de Celis and Bray, 1997).
As development proceeds, gap gene cross-repression refines the pattern (see Jaeger, 2011 for review).
The transcriptional circuit composed of Gap genes that operates along the anterior-posterior axis of the Drosophila embryo appears to refine and stabilize the patterns of gene expression generated by differential responses to a gradient of Bicoid (Manu et al., 2009b).
A quantitative analysis of VO and Zni was performed to explore this hypothesis; we refined the XRD patterns of the samples.
