The model from Manceau and coworkers [70] was used to refine the patterns.
Furthermore, despite the proselytising tone of A Pattern Language, its introductory discussion states that it was published as a work in progress and encourages readers to continue to refine the patterns contained therein and develop their own new patterns.
In order to refine the patterns of chromosomal imbalances present in cervical carcinoma, and trying to identify specific genes that might be targets of copy number changes in this tumor, we applied microarray CGH on 20 uterine cervix-derived samples (three pre-malignant lesions, 10 invasive tumors and seven UCC derived cell lines) to detect DNA copy number changes at the single gene level.
As development proceeds, gap gene cross-repression refines the pattern (see Jaeger, 2011 for review).
Future work could involve refining the pattern extraction process, perhaps to enable sentence-level pairing using more sophisticated association techniques (e.g. dependency parsing or syntactic structure).
Drosophila deletion mutants show a sporadic loss of sensory bristles, revealing the role of this miRNA in ensuring the developmental 'robustness' of patterning processes (for example by protecting interommatidial bristles during the programmed cell death that refines the pattern of the pupal retina).
Together, these studies identify an important role for the transcriptional circuit in refining the pattern of gene expression in the neural tube, but it leaves unresolved the question of how different levels and durations of Shh signaling control appropriate gene expression in responding cells.
Using this model, we discuss evidence for how "zebra-like" patterns in Purkinje cells sculpt the cerebellum, how specific genetic cues mediate the process, and how activity refines the patterns into an adult map that is capable of executing various functions.
Further innovations have included using multiple discontiguous seeds and refining the patterns of the seeds [ 11, 12].
This Notch activity drives the expression of the Notch target genes E spl), Wingless, and Cut, which together refine the expression patterns of Notch ligands and regulate the spatial pattern of Notch activation in subsequent stages (de Celis and Bray, 1997).
