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Different classes of small RNAs (sRNAs) refine the expression of numerous genes in higher eukaryotes by directing protein partners to complementary nucleic acids, where they mediate gene silencing.
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This Notch activity drives the expression of the Notch target genes E spl), Wingless, and Cut, which together refine the expression patterns of Notch ligands and regulate the spatial pattern of Notch activation in subsequent stages (de Celis and Bray, 1997).
The results detailed here refine our understanding of the expression of chemokine receptors in osteosarcoma.
First, we refined the expression patterns of human KLFs from mRNA-seq data and proposed that the higher expression of eight KLFs in erythroid cells may be ascribed to the presence of erythroid-specific enhancers.
miRNA-target pairs computed by TargetScan [ 65] were further refined by the expectation that the expression of miRNAs and their target genes is negatively correlated [ 66].
The expression of cact3 does not refine into a more narrow domain, but remains broad during later blastoderm stages.
Subsequently, the expression of ac and sc refines to single sensory organ precursors (SOPs) where high levels of Ac/Sc activate the third gene, asense (ase), whose expression is limited to SOPs [ 10- 13].
This induces the expression of the Wnt protein Wingless, which refines this stripe of Notch activity in two ways.
Here, we report that the transcription factor Zic2 regulates directly the expression of the serotonin transporter (Sert) in iRGCs to refine eye-specific projections in primary visual targets.
Importantly, the expression of a number of selected novel or refined transcripts including putative lncRNAs was verified experimentally in bovine skin and in several bovine tissues.
Our data support a model where Hairy in the somatic muscle, normally refines the spatial expression of bnl in the muscle cells that are in close proximity to the migrating tracheal branches, such that only a single cell at the tip of each dorsal branch becomes specified as the terminal cell.
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