Leptin does not appear to need to be in phase with melatonin to present an effect, as already demonstrated in diurnal animals (ewes), but in the rat, since both hormones peak during the night phase, this could refine the modulatory effect of leptin on melatonin synthesis.
The need for large samples to refine the study of effects of modest magnitude and the necessity to replicate studies across different ethnic backgrounds rely on easy access to a large variety of data organized in a systematic way.
To refine our knowledge regarding the effect of Nef on dendritic cells, we developed constitutive and inducible adenovirus vector systems that express high levels of Nef in monocyte-derived dendritic cells (MDDCs).
However, these associations between loci and fitness need more refining to validate the effect of individual genes.
Overall, these data suggest that GDM screening protocols that include the GCT should be refined to account for the effect of time of day on test performance.
Appropriate further directions to refine the understanding of these effects would include an examination of syntax comprehension, like that assessed in this design, presented in paragraphs of text alongside higher-order pragmatic questions.
Recent research has called special attention to the need to refine models with respect to the effect of clouds and the carbon cycle.
In a recent meta-analysis of surfactant lavage, Hahn et al. state that lung lavage with diluted surfactant may be beneficial to infants with MAS, but additional controlled clinical trials of lavage therapy should be conducted to confirm this effect, to refine the method of lavage, and to compare lavage with other approaches [ 48].
It enables users to interactively combine attributes and flexibly refine parameters to explore the effect of changes in the attribute combination.
13 Using that data in conjunction with supervisory and publicly available datasets, the Board will be able to draw not only upon the experience of the United States but also that of other countries to refine estimates of the effects of changes in the CCyB.
