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Its design of providing a "physiologic snapshot" of the injured child on presentation has supported numerous studies that have helped define the epidemiology of childhood injury and refine principles of management.
In the light of 3R (replace, reduce, refine) principles in animal experimentation and increased focus on delayed effects of treatment on central nervous system, the incorporation of behavioural tests into standard toxicology studies as a complement or substitution of a stand-alone safety pharmacology study appears very attractive, but poses some challenges.
Experts may debate and refine principles of justice to prioritize effective interventions but if social, political, or economic barriers prevent implementation, this represents a failure of practical distributive justice.
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Then we have to test those hypotheses and refine the principles until our model gets better.
The team has continued to refine the principles, which are explained on its web site.
These results help refine design principles and expectations for polyamide DNA recognition.
A group called the International Capital Market Association has convened issuers, buyers, and underwriters of green bonds to update and refine the principles.
Only by repeating and disputing the law can we refine the principles to make the wheels of our system of justice roll down the road of righteousness.
So that they are not themselves seen as arbitrary, the courts are constantly developing and refining general principles of judicial review.
An approach to implementing SGA is defined and refined, indicating principles which may be used in applying the method to other engineering problems.
He begins with some very entertaining evolutionary speculations — it's not clear how literally we should take them — that show why the following principle should be true of us humans: Confusion —> Understanding —> Pleasure (CUP) From here he goes on to discuss and refine the principle, relating it to humor and the "one-liner" joke.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com