For instance, it could be possible to refine pathways across conditions or to identify new subgroups within one condition.
Further studies using large-scale datasets and refined pathway knowledge are highly demanded, which could increase the effectiveness in detecting pathways with modest effects.
The initial PT will be tested and the resulting refined pathway may provide useful information to be used by programme implementers, policymakers, donors and the community.
A comprehensive comparison of the modeling results showed that from a process engineering standpoint, the feasibility of the biomass refining pathways ordered from high to low is gasification chemical synthesis, hydrolysis fermentation, then gasification biosynthesis.
Therefore, to refine the pathway of change and enhance elasticity of the ToC map, follow up ToC is required.
Increasingly, it is now experimental data that is helping to refine existing pathway models and observations that we do not understand that are driving our current modelling efforts.
Therefore, although studies in neurodegenerative diseases and specifically, Parkinson's disease, might not usually be considered cancer research, they could ultimately provide insight into the function of genes and mechanisms associated with cancer, and help to characterize and refine biological pathways and/or therapeutic targets.
We undertook a feasibility study to refine patient pathways, and the CCQ and economic health resource-use questionnaires.
However, we believe that having now developed and refined the pathway over several years it is now ready to be implemented in broader settings.
As a proof-of-concept that connected hubs identified by WGCNA are of biological relevance, we further refined the pathway analysis by focusing on kinases, since these tend to be of the greatest translational value.
