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The ability to refine diagnostic categories will allow specific treatments, whether in oncology, cardiology or diabetes care.
The application of new multiphoton imaging methods to archived medical specimens could provide new insight into disease progression and help refine diagnostic criteria for accurate early detection.
The use of proliferation markers, such as Ki-67, may help to confirm these differences and refine diagnostic criteria, particularly for well-differentiated perianal gland carcinomas [ 1].
11 12 13 There is a need for more "diagnostic research" to generate the evidence base on which to refine diagnostic criteria in primary care and to develop decision rules for the management of symptoms and symptom complexes.
The study demonstrated the importance of validation studies to better understand the system(s) used, to highlight potential limitations in specific target regions, and to identify robust and/or inconclusive sequences to refine diagnostic interpretations.
In relation to haematuria (blood in the urine) and the diagnosis of urological malignancy two of the authors of this paper (NS and ASR) have used Bayesian techniques in order to seek to refine diagnostic discrimination by general practitioners [ 9].
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In conclusion, we developed a new, refined, diagnostic tool for identifying LVNC, based on an a priori assessment of the trabecular architecture in healthy volunteers.
However, there is room further improvement in the development of rating scales and more refined diagnostic criteria as well as better reporting of some aspects of trial methodology.
APRDRG = All-patient refined diagnostic related groups, HMO = Health maintenance organization.
Genes identified in this fashion can then be utilized as more refined diagnostic tools.
Variables for major diagnostic categories (MDC) and Australian Refined Diagnostic Related Groups (AR-DRG) were also provided.
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