Their tasks were to review the relevant scientific evidence, examine available ambient concentration data, oversee the assignment of substances to specific risk-based categories, and then to use their collective judgment to refine these assignments as necessary.
As more annotated assemblies become available, we should be able to test and refine current assignments of orthologous and paralogous relationships.
Refined compartmental assignments (Data S4) were performed using a classification tree based on observed subcellular distribution (Figure 6) and marker-'free' by means of robust k-medoids clustering (PAM, partitioning around medoids).
Alvin et al. [3] further refined this assignment and have reported that the dominant conifer in this environment was Pseudofrenolopsis parceramosa, creating stands wherein Brachyphyllum obesum grew beneath the canopy.
Long-range NOE restraints and backbone chemical shift fragments guide the generation of batches of preliminary, low-resolution structures, that are in turn utilized to evaluate and refine the NOE assignments.
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The reconstructed regulatory network allowed us to suggest and refine specific functional assignments for sugar catabolic enzymes and transporters, providing a substantial improvement to the existing metabolic models for B. thetaiotaomicron.
This pattern has been recognized before (Hoiczyk et al., 2000; Tahir et al., 2000) and named NSVAIG-S; we use it to refine the repeat assignments in Ylhead domains as described in the Methods.
Representation-based methods iteratively refine a cluster assignment and representative (such as the centroid) of the cluster.
In addition to structural changes, gene names were systematically refined and Gene Ontology assignments were applied.
This is used to encode more efficient PB constraints and enables the algorithm to obtain assignments and refine also the upper bound.
