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Total duct dependent circulation cohorts: West Götaland n=60, other referring regions n=100.
Among the population from other referring regions 19/33 (58%) of babies with severe acidosis had systemic duct dependent circulation.
No baby died from undiagnosed duct dependent circulation in West Götaland versus five babies from the other referring regions.
23 This compares with 4.4/100 000 in the Newcastle area in 1985-2004, whish isimilarar to the 4.6/100 000 found in the other referring regions for 2004-2007 in this study.
(We used full 12 month periods for 2004 and 2007 in the other referring regions cohort in order to obtain correct birth numbers through official statistics).
In all other referring regions, not using pulse oximetry screening but some with prenatal screening by echocardiography, 109/108 604 newborn infants had duct dependent circulation (birth prevalence 1.00/1000).
We excluded those babies with a prenatal diagnosis of duct dependent circulation (two in West Götaland, nine in the other referring regions).
Between 1 July 2004 and 31 March 2007 no children with undiagnosed duct dependent circulation died in West Götaland (0/60) compared with 5/100 in the other referring regions (P=0.16).
There may be other differences besides the use of pulse oximetry screening that contributed to the lower detection rate in the other referring regions (some differences between the referring hospitals were documented in a previous study 3).
However, the detection rate in the referring regions was as good as or marginally better than that documented in the Newcastle region over 20 years, 4 so it was probably a representative average.
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