During 2007-08 a total of 611 women from five reference laboratories in Catalonia with a novel diagnosis of ASC-US were referred for high risk HPV (hrHPV) triage using high risk Hybrid Capture version 2. Using routine record linkage data, women were followed for 3 years to evaluate hrHPV testing efficacy for predicting CIN2+ cases.
The remainder were ascertained by queries of databases of patients referred for high-resolution genome analysis for a variety of reasons.
Using BAC clone and oligonucleotide array CGH, we identified overlapping microdeletions in 16q24.1q24.2, ranging in size from ∼100 kb to ∼3.5 Mb, in seven patients referred for high-resolution genome analysis.
Three patients carried causative mutations in Ryanodine receptor-I (RYR-I); of these, 2 were referred for unexplained high CK, and 1 was referred for exercise-induced rhabdomyolysis.
Women referred for delivery had higher CS rates and poorer neonatal outcomes, suggesting that the formal referral system successfully identifies high-risk birth, although low volume suggests underutilization.
All patients in this category will be referred for Specialised Treatment (high-intensity Intervention) with an appropriately qualified practitioner via a pre-defined clinical pathway at the respective site.
Another study of HPV prevalence in liquid based cytology specimens of 594 patients from the NZ-NCSP referred for colposcopy with high grade cervical lesions between 2009 and 2011, reported a HR HPV prevalence of 86.7% [ 22].
The optimal proportion of patients diagnosed with cancer who should be referred for genetic assessment for high or moderate risk was calculated to be 0.06, that is, 6% of all patients diagnosed with cancer in Australia should be referred for genetic assessment, based upon the best available evidence.
Students who have experience trauma are more likely to be referred for special education, have higher rates of school discipline referrals and suspensions, lower test scores and grades, and are less likely to graduate.
One explanation may be the increasing attention for (hereditary) breast cancer in the media in recent years and the fact that more women and their families ask to be referred for counseling, suggesting a higher current awareness of familial risks.
