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Of the three exercise referral studies, one involved referral to a leisure centre based programme, one to a community walks programme, and one involved small group exercise sessions at an unspecified location.
[ 19] Referral studies, in which patients meeting pre-specified criteria are triaged for further investigation, tend to exclude those aged over 45 years which may be a factor, although the populations are different in other ways.
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Clinical symptoms of TB of this referral study population included cough (67.7%), fever (80.2%), weight loss (45.8%) and chest X-ray consistent with TB (75%) (Table 2).
Six genes were selected for testing in Predictors 1, a colposcopy referral study comprising 799 women.
In the current manuscript we describe the study protocols of two related studies: a referral study and an intervention study.
Recruitment of participants takes place via the referral study, the Internet, the media, and rehabilitation centers and hospitals in the Netherlands.
This further minimises case ascertainment bias related to variations in geographical accessibility to the main referral study site.
In the referral study we will explore if the Pain Barometer, the signaling and referral instrument, is feasible in the context of preventive Youth Health-Care.
The three genes EPB41L3, DPYS and MAL were further tested in a second colposcopy referral study, Predictors 2, comprising 884 women.
A limitation of the referral study is that it is not possible to explore the validity of the Pain Barometer in this setting.
This referral study was a sub-study of a cluster randomized controlled trial known as Good Start Saving Newborn Lives (SNL) which was implemented in KwaZulu-Natal province between 2008 and 2011 (ISRCTN41046462).
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