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The references were selected by Drs. Paul Offit and Stanley Plotkin.
References were selected on the basis of both temporal and thematic relevance, and subsequently aggregated around four distinct themes: the uses of CDSS in the critical and surgical care settings, clinical insertion challenges, utilization leading to cost-savings, and regulatory concerns.
References were selected from the following oncology journals that usually deal with phase I trials: Annals of Oncology, European Journal of Cancer, Journal of Clinical Oncology, Clinical Cancer Research and Investigational New Drugs.
Additional references were selected from relevant papers.
The different references were selected for their unaltered expression in each of the treatments.
After reviewing these, 22 references were selected for detailed review (Table 1).
Similar(42)
This is due to the relatively larger background areas in these three cases, and hence a larger number of references are selected from the McFIS.
Significantly differentially expressed genes (outliers) between sample and reference were selected based on their P-value (a gene with a P-value <0.05 was considered an outlier).
TaqMan probe and primer sets, including 18S rRNA for use as a reference, were selected from the Applied Biosystems web site following the UNIGENE accession number and/or Affymetrix probe set ID for each target.
In order to construct a matrix, 40 of the cross-references were selected with references present in all entries removed as well as RefSeq, which had an identical number of entries with Entrez Gene database.
Differentially expressed genes between sample and reference were selected based on their P-value (a gene with a P-value < 0.01 is considered an outlier).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com