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The dataset for CASMI 2016 was predominantly well-known anthropogenic substances and as a result there are many distinct and highly referenced substances in the candidate lists.
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The functionality was demonstrated by calibration with different reference substances.
For that purpose, a set of reference substances preconized by the Organization for Economic Cooperation and Development (OECD) guidelines was used.
After measuring the manuscripts, we compared these results with reference substances.
Skin permeability to both reference substances was significantly higher compared to published mammalian data.
Dermal absorption and uptake were quantified using two reference substances, caffeine and testosterone.
Indacaterol maleate and glycopyrronium bromide reference substances were kindly provided by Novartis (Basel, Switzerland).
Due to missing reference substances, transformation products are often determined only qualitatively.
Artemisinin and scopoletin (each 1 mg/mL) were used as reference substances (Sigma-Aldrich, Taufkirchen, Germany).
Within the class of PFC chemicals, perfluorooctanoic acid and perfluorosulphonic acid are generally considered reference substances.
The toxicity results of reclaimed water were converted into the equivalent concentrations of the corresponding positive reference substances (EQC).
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