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The methodology developed is proposed as reference test for the evaluation of current and future automotive fuels as regards their tendency to form deposits.
The pp65 antigenemia assay has been used as reference test for monitoring active CMV infection and guiding preemptive therapy in transplant recipients.
The assays developed were shown to be highly sensitive and specific in comparison with the viral neutralization test, which is the reference test for the serological diagnosis of BVDV.
Basara et al. (2013) used histopathological examination as a reference test for malignant lymph nodes and clinical examination with imaging findings as reference for benign lymph nodes.
We have also quantified the probable false negatives of bacteriological culture, which is currently the reference test for TB diagnosis.
Bacteriological culture is the reference test for TB diagnosis, as specificity is 100% [1], [8]; nevertheless false negative results do occur [19].
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The department has a major commitment to our extended community outside the Medical Center and offers both a variety of blood drawing stations and satellite laboratories in greater New Haven as well as reference testing for other hospital laboratories, medical practices, and institutions.
In this regard, the bioassays (hemolytic and brine shrimp) are the standard tests to evaluate the cytotoxicity, whereas TA98 and TA100 (based on salmonella mutant strains) are the reference tests for mutagenicity evaluation.
A validation study comparing reference tests for C. difficile (toxin assay positive versus cytotoxigenic C. difficile culture positive/toxin assay negative) showed that detection of toxins was associated with more severe CDI outcomes [ 17].
Moreover, the thorough evaluation of reference tests for intestinal pathogens can serve as diagnostic 'gold' standard in the standardisation and validation of easily applicable RDTs, which are highly needed tools in resource-constrained field settings.
The data collection methods most often mentioned concerned a retrospective review of (medical) records (11 studies), a questionnaire or interview (8 studies) and reference tests for diagnosing GERD (10 studies).
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