We used event_simulator to simulate 100 fusions, 100 PTDs, and 100 ITDs using Ensembl v59 gene annotations and the GRCh37-lite (hg19) human genome reference sequence, restricting our simulations to genes on chromosomes 20 and 22 (see Additional file 1: Section S17 for the parameters used, see Additional file 2 for the simulated events).
A typical SNP and INDEL calling pipeline based on alignment to a reference is restricted by the reference.
Alternatively, in a solution advocated by the 'restringentes [restrictors]' so-called because they avoided self-reference by restricting what a term can supposit for—we could make the proposition non-reflexive by stipulating that "terms that are apt to supposit for propositions are not put in propositions to supposit for the propositions in which they are put, but for others".
One, last October, was a success (although its terms of reference were restricted), while the second, in January, narrowly failed.
It's not one of Kurosawa's great films; the compass of feeling is, in the end, too narrow, the scope of human reference too restricted.
This finding is relevant for astronauts who are normally aware of their surroundings, and it is in accordance with previous findings, where only egocentric stimuli were impaired in microgravity when sensory cues about the vertical reference were restricted.
The adoption of the annual reference flow restricts the grants of water use in most of the time, because the proposal of monthly and seasonal Q 95% in the rainy period for grants processes showed much higher values.
It was observed that the adoption of the annual reference flow restricted the grants of water use most of the time, since the proposal of monthly and seasonal Q 95% in the rainy period for the granting processes presented values much higher.
His terms of reference were restricted to the question of whether Drew was personally responsible for the establishment of "a secret political police organization, for the purpose of collecting, by secret spying, material to be used in attempt to keep him in power.
However, limitations on the availability of a reference genome restricted the amount of information obtained, and phylogenetic distances between these insects may influence the response mechanisms to Cry toxins.
