Exact(20)
More tests are required with homologous reference preparations.
Licensing authorities in Europe recommend use of single-dilution assays for some vaccines, together with homologous reference preparations.
The results obtained with various assays show wide variability due to differences in the antibodies used and the distinct reference preparations employed for the calibration of assay kits.
Analysis of tumor-tissue based international reference preparations (RBG EORTC 101094 and 040297), human anti-mouse antibodies (HAMA) containing sera, and sera from patients with rheumatoid arthritis (RA), also displayed no false positive signals.
From the diagnosis standpoint, both, functional (clotting) or immunological assays, are difficult to standardize and to optimize, due to the absence of reference material, or a characteristic clinical group, and international reference preparations.
Quantitative ELISAs were identified that accurately measured each allergen, except for rPhl p 1. The CREATE project has provided a major step forward in allergen standardization and provides a model for the development of a comprehensive panel of international reference preparations that will harmonize allergen measurements worldwide.
Similar(40)
The in-vivo study in rat demonstrated that Cmax and AUC0→12 values of nanosuspension were approximately 2.8-fold and 2.7-fold greater than that of reference preparation respectively.
The Cmax, MRT, AUMC0→∞ and AUC0→∞ values of SLN were approximately 1.6-fold, 1.9-fold, 5.0-fold and 2.6-fold greater than that of reference preparation, respectively.
All methods are standardized with the reference preparation (IRP MRC 65/93) and use International Units (IU), except for CEN and KRY whose results were initially expressed in Arbitrary Units and then converted in IU (Table 1).
All methods were standardized with the reference preparation MRC 66/387 and used international units (IU), except for KRY whose results were initially expressed in arbitrary units and subsequently corrected in IU (conversion factor = 0.175).
In fact, over the years, there has been an improvement in the harmonization among methods, due to automation of the analytical procedures and the use of the same reference preparation (MRC 66/387) [10].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com