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This test is done on healthy volunteers and compares the blood levels of the reference drug to the generic one.
5-FU was used as the standard reference drug.
Amoxyclav (Himedia SD063) disc was used as a reference drug.
The results were compared to Captopril as a reference drug.
cruzi activity in comparison to the reference drug, benznidazole (BZN).
These were lower than that of the reference drug, miltefosine (0.46 µM).
Most of the tested compounds showed excellent antibacterial activities with respect to the reference drug.
Cytotoxicity was evaluated using HT-29 (human bladder carcinoma) with podophyllotoxin as reference drug.
Adriamycin (ADM) was chosen as a reference drug due to its availability and widespread use.
In some experiments, serial dilutions of 6-MP, as reference drug, were added.
Thus, an affordable reference drug library obtainable for all screening centers is still missing.
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CEO of Professional Science Editing for Scientists @ prosciediting.com