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In phase 1B, the antagonistic activity of FLU to TP was detectable in all five of the androgen-sensitive sex accessory tissues in a dose-related manner with both reference doses of TP.
In 2009, the American Heart Association AHA Science Advisoryrecommendedded the reference doses of common cardiology examinations [ 12], and in 2010 the ACC committee also expressed the need for appropriate and optimal use of radiation techniques in cardiology [ 13].
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An ARfD (acute reference dose) of 0.5 mg/kg bw was derived from the NOAEL of 50 mg/kg bw/day, applying also a safety factor of 100.
Health risk index (HIR) for all HMs were less than 1, which is may be due to the high level of allowable oral reference dose of the respective metal and this indicate no risk.
Although all study participants had measurable perchlorate levels in their urine, none of the exposure doses exceeded the U.S. EPA reference dose of 0.70 µg/kg/day.
This dose exceeded the daily oral As reference dose of 0.3 μg kg-1[ 49].
RT was applied with linear accelerator photons to a reference dose of 50.4Gy in 1.8Gy fractions.
A chronic oral reference dose of 3 μg/kg/day is given for ingestion of Cr VI) (U.S EPA 1998).
Similarly, the United States Environmental Protection Agency US EPAA) derived a reference dose of 0.05 mg/kg bw/day (reviewed by Willhite et al., 2008).
Mercury levels were well below the Environmental Protection Agency reference dose of 5.8 mg/L in all but one adolescent.
We believe that the committee's recommended reference dose of 0.0007 mg/kg per day provides a wide margin of safety for all subjects of all ages.
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