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These combinations were examined in a case-control study comparing pair-wise the frequencies of obese versus lean individuals for each combination against a reference combination (Figure 1A).
However, a nominal significant difference in measures of systolic blood pressure as well as mean arterial blood pressure was observed between the reference combination and haplotype combination 2,4 with the latter having an increased blood pressure (Table 2).
In order to assess the synergistic effect of the SDF1-3′A polymorphism and CCL3L1 CN, SDF1-3′A andele and CCL3L1 > 2 copies conferring a protection to HIV-1 were considered as reference combination.
Kim and Yoon [ 13] presents an adaptive reference update (ARU) algorithm to search for the optimal drug combination by comparing the response of the current combination against that of the reference combination and beneficially updating the drug concentrations.
Therefore, at the end of 90's, cyclophosphamide-epirubicin-5FU (FEC) regimen became the reference combination in France for adjuvant chemotherapy in early BC, epirubicin 100 mg/m being shown as more effective than 50 mg/m in a comparative randomized trial [ 4].
For men, reporting a non-traditional childcare at age 42, combined with traditional as well as non-traditional childhood, was associated with decreased risks of depressive symptoms (84% and 78%, respectively) (all estimates compared to the reference combination of traditional adulthood/traditional childhood).
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Thus, once the optimal reference source combinations were determined as described above, alternative datasets were used to re-determine the optimal weights (omega _{{mathrm{Frag}}}), (omega _{{mathrm{RT}}}) and (omega _{{mathrm{Refs}}}) to investigate the variation over different datasets.
As responses with standard reference combinations of irinotecan + capecitabine or oxaliplatin + capecitabine are observed in about 40 50% of patients, a response rate ⩾70% for a new regimen that has acceptable toxic effects would be considered promising.
If one phenotype from one reference is applicable to multiple genes, the curator may enter additional gene names, and the phenotype-reference combination will be associated with all the genes.
Stimuli order: Each modified and reference mesh combination was presented in a random order allowing for more accurate comparisons.
To evaluate prospectively the validity of a «rapid» serology diagnosis method (using capillary blood) in our ambit, taking for reference a combination of standard diagnostic methods.
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