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The same reference chemicals: lindane, copper, 3,4-dichloroaniline and atrazine were used by all laboratories.
This involved the blind-testing of 56 reference chemicals on the HTS platform to produce concentration response and IC50 data.
Data for 97 reference chemicals was collected in the ACuteTox database (Acutoxbase), designed to handle in vitro and in vivo (human and animal) lodged data.
Results generated with selected reference chemicals compared very favourably with data obtained from a previous international validation study concerning the prediction of acute systemic toxicity in rodents.
In contrast, the revised tool successfully delineated vulnerable areas to the selected VOCs based on two reference chemicals, a known leacher and non-leacher, which were determined in local conditions.
In the course of the study 97 reference chemicals were tested in ∼100 in vitro assays, including models for general acute cytotoxicity, metabolism-mediated toxicity, biokinetics, haemato-, immuneuro-,uro-, nephro-, and hepatotoxicity.
Similar(6)
The intra- and inter-laboratory reproducibility of the proposed protocol with a soluble reference chemical K2Cr2O7 was good, which confirms the suitability of this assay for conventional chemicals.
This study was designed to assess the accuracy of whole-blood glucose measurements from the glucose meter relative to a reference chemical analyzer in a diagnostic laboratory.
μ0 is the reference chemical potential of the planar surface.
According to the reference chemical approach, temperature correction, therefore, does not seem justified" [7].
We used PubChem Compound as the reference chemical space, so the we needed to cover about (10^8) molecules (leaves).
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CEO of Professional Science Editing for Scientists @ prosciediting.com