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In this section, our terms 'selective' and 'non-selective' refer to selection based on mitochondrial function; we assume that mitophagy always selects on mitochondrial size (i.e. only small mitochondrial fragments are targeted for mitophagy).
We refer to selection for the intermediate allele as the look-ahead effect, because this effect allows evolution to select for sequences not yet in the genome.
The presented investigation results refer to: selection of the tool material for a particular process, its adequate thermal and thermo-chemical treatment, use of surface engineering techniques: hybrid with the use of coatings applied physically from the gaseous phase, use preventive pad welding, as well as optimization of the die shape and construction of the instrumentation set.
Patients will be recruited from pharmacies and will be randomly allocated into control group and intervention group (refer to Selection process, randomisation, intervention allocation and blinding section).
We have further re-read the entirety of the manuscript to look for instances in which we explicitly refer to selection occurring on a 'strain', but have not been able to identify any such instances.
The success or failure of a beneficial antigenic mutation is a complex process, and while the authors do not need to incorporate all aspects into their model, they should be explicit about what is not being factored in: 1) The authors refer to selection as occurring on a 'strain', whereas in reality mutations are occurring within a swarm (quasi species) of intrahost diversity.
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Genomic selection refers to selection decisions based on genomic estimated breeding values (GEBV) [ 1].
The conservation of gene organization could be explained by purifying selection (or negative selection) that refers to selection against nonsynonymous substitutions of protein-coding sequences.
For more details, please refer to parameters selection in the "Performance evaluations" section.
In the following we only refer to the selection intensities (i) as this is the standardised parameter that can be directly compared with the effect of genetic drift.
As such, the explanation would refer to a selection of more healthy individuals in larger families.
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