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In a suspected case of maternal depression, trained public health nurses usually perform two or more home-visits and confirm depressive symptoms by interviews, e.g., Mini-International Neuropsychiatric Interview [ 37], and refer subjects with marked depressive symptoms to psychiatrists.
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A printed referral letter was provided to the referred subjects.
The WRCC, the area's regional cancer treatment center, referred subjects to this population-based case control study.
Participants were recruited from a sample of referred subjects, and consequently are not necessarily representative of children and adolescents with ADHD in the general population.
Thus, the population with IBS is heterogenic and the results may not be compared with results from studies of merely referred subjects.
It should be noted that findings of this study cannot be generalized, as the study included a relatively small sample consisting of clinically referred subjects with significant impairment.
As we discussed above, including clinically referred subjects with significant impairment can be considered an ascertainment bias that contributed to the high rates of psychiatric comorbidity and family history of OCD and a male predominance within the sample.
The recruitment target of 30 participants per group was calculated on the basis of a similar number of referred subjects in two previous studies on chronic fatigue syndrome [ 48, 49].
The study will be promoted to all the staff of these craniofacial clinics so that they also can assist in identifying and referring subjects to the study and will be advertised in local media.
Therefore, we can only speculate that personnel in primary care also referred subjects to the Center with faint test lines who afterwards tested negative at conventional serology, as shown in a previous study [ 25].
"American" is rarely used in English to refer to subjects not connected with the United States.
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