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The binding interface of calmodulin and a calmodulin binding peptide were reengineered by computationally designing complementary bumps and holes.
Therefore, the ATP driving force module was reengineered by providing a reversible outlet for excessive carbon flux.
Spinach has been reengineered by extending its 5′- and 3′-ends to create Spinach.ST, which is predicted to fold into an inactive conformation that fails to bind DHFBI.
In order to reduce that effect in a cost-effective manner, the traditional distribution grid planning process is being reengineered by incorporating the grid control operations and considering the uncertainties e.g., DG power, demand and urban/rural expansion plans.
In cases where the kinetic data were not available, the data were reengineered by using a proprietary algorithm that aligned predicted data sets to published data under various growth and inhibition conditions.
As nascent TNFR ECD is a large therapeutic molecule that does not cross the blood brain barrier (BBB), it was reengineered by fusion of the receptor protein to the carboxyl terminus of the chimeric monoclonal antibody (mAb) to the human insulin receptor (HIR).
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Triggered by 2 major outbreaks of verocytotoxin-producing Escherichia coli (VTEC) in Japan (1, 2 ), the nationwide surveillance system of the National Institute of Infectious Diseases (NIID) was reengineered in April 1999 by enacting a new infectious disease prevention law to better ascertain the state of laboratory-confirmed VTEC cases across the nation.
Since we had to overcome the paucity of kinetic data for M. tuberculosis enzymes, we reengineered the parameters by using a proprietary algorithm that aligned predicted data sets to published data under various growth conditions and a large set of MIC data for various antitubercular agents in stand-alone and doublet combination mode.
We reengineered the native FliC structure by replacing the FliC D3 domain to contain a conformationally intact DENV2 E protein domain, without compromising either protein's structure.
To target vaccine responses from T-independent B cells, we reengineered a bacterial Flagellin (FliC) by replacing its exposed D3 domain with a viral envelope protein from Dengue virus (DENV2).
The d-lactic acid producing strain, Escherichia coli HBUT-D, was reengineered for l-lactic acid fermentation by replacing the d-lactate dehydrogenase gene (ldhA) with an l-lactate dehydrogenase gene (ldhL) from Pedicoccus acidilactici, followed by adaptive evolution in sucrose.
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