It is likely that partially functionally redundant histone modifications, such as mono- or dimethylated H3K4 or lysine 9-acetylated histone H3, may be sufficient to promote an active chromatin configuration in the absence of H3K4me3.
A number of minor changes to the ORACLe interview were proposed following pilot testing, including the removal of redundant questions, modification of item wording, and inclusion of additional items to address other research resources (e.g. knowledge management systems).
Items that had factor weights < .40 were removed, as well as those that were redundant by the modification indices estimated by the Lagrange multipliers (LM) method (LM > 11, p < .001).001
In such studies it will be important to determine which genomic modifications are redundant and which are functionally relevant to the disease.
Because the Model stores the document state, it is not necessary to insert all the document elements again, only the modifications made, avoiding redundant processing of the primitives.
As some features might be partially or fully redundant (e.g. histone modifications) and some may add no or little predictive value, we modified our approach and used a LASSO regularized multinomial logistic regression model [ 25, 26] to assess features systematically and obtain their rank contributions to the classification of enhancers.
Within the constraints of a linear model, DNA methylation and the four considered histone modifications are statistically redundant with respect to gene expression.
Histone code is redundant in the sense that different modifications on the same histone tail can result in the same chromatin conformation (rf. Table 1).
Overall, our analysis proves that not only there is non-redundant information between motifs and epigenetic modifications, but we can show that it is enough to get near-perfect predictions of enhancer activity.
This result explains why NOCA-1h localization at compartment surfaces was not eliminated by γ-tubulin depletion and implicates a potential lipid modification in providing a redundant means for NOCA-1 targeting to the membrane.
