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As most BH3-only proteins show a redundant interaction pattern with different Bcl-2 pro-survival homologues (Chen et al, 2005), it currently remains unclear which BH3-only protein(s) regulate HSPC numbers under steady-state conditions or in response to transplantation stress.
Generally speaking, a redundant interaction is any interaction that can be removed from the network with no phenotypic effect, i.e. without causing changes in the temporal expression pattern [ s(0),..., s(t P )]; however, as the example in figure 4 shows, the phenotypic effect of removing a link may depend on how it is removed.
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I remember him becoming uncharacteristically agitated as he described how some individuals misunderstood medical training, particularly the revolving and redundant interactions between the doctors-in-training, the fully trained attending surgeon and the patient.
Limited proteolysis reveals that eIF3 binding to the 40S ribosomal subunit occurs through many redundant interactions that can compensate for each other.
miRNA → Target Gene link: data taken from the TarBase database, v. 5.0 [20] and from the miRecords database, v. 1.0 [21] for a total of 1276 non redundant interactions.
After removing redundant interactions, the interaction data contained 43 687 unique physical interactions and 10 735 GIs.
The NCBI Entrez GeneID was used to catalog interactions and redundant interactions were removed.
All of the redundant interactions were removed in constructing DG interaction map.
To remove redundant interactions, UniProt Knowledgebase (UniProtKB) accession numbers are used as unique protein identifiers.
Redundant interactions were removed, along with interactions with identifiers that could not be mapped to gene symbols (Table 1).
All the redundant interactions were removed and the remaining interactions represented as networks using Cytoscape (http://www.cytoscape.org/).org/
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