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Large-scale genetic screening is a particularly effective means to establish a wiring diagram of functional relationships for genes of unknown or redundant function (Costanzo et al. 2011).
This variability in ISG15 sequence may indicate a redundant function of ISG15.
They also show a completely redundant function caused by rather subtle adhesion defects.
Nevertheless, we cannot rule out the possibility that a redundant function may exist in pollen.
While other studies have demonstrated a lack of redundant function for two or more Mecps in silencing of specific loci (e.g. [41]), this study provides the first evidence for a redundant function of Mecps in mammalian cells.
However, AC4 in TGMV which is also bipartite begomoviruse showed either no function or redundant function with other TGMV encoded proteins [34].
In summary, we conclude that there is a redundant function for Caps and Trn in controlling aspects of cell morphology and ommatidial spacing in Drosophila retinal development.
Thus we conclude that the defect observed in triple knockout NS cells likely results from some redundant function between these three proteins.
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Recently, several studies have shown that certain HDAC family members are aberrantly expressed in several tumors and have non-redundant function in controlling hallmarks of cancer cells.
Together, these results reveal a non-redundant function for RelB in TEL-JAK2-induced leukemogenesis.
Simultaneous RNAi knockdown of both RabX1 and RabX2, while partial, was also non-lethal and may suggest non-redundant function, consistent with the distinct locations of the proteins.
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