Sentence examples for redundant alterations from inspiring English sources

In this sense, the somatotropic axis alterations found in Zmpste24 −/− progeroid mice represent an example of over-suppression of a growth-promoting pathway, as they show multiple and probably redundant alterations in regulators of GH-mediated signaling.

The evidence that the same functional endpoint can be achieved by distinct chromatin marks shows that the cell has available multiple, redundant pathways for effecting local alterations of chromatin structure that regulate homologous recombination.

Somatic mutations in K-Ras and EGFR are mutually exclusive in NSCLC [89], suggesting that gain-of-function alterations are non-redundant and often occur at one node of the signaling cascade.

It is plausible that these patients are the ones that have only a BRAF alteration, or only alterations that influence a redundant signal.

Although we detected no significant alteration of response diversity, functional redundancy of litter-invertebrate communities decreased clearly by losing 37% of functionally redundant species due to land-use change.

As our phenotypic studies in podxl embryos did not show radial migration alterations, NCAM and PC may have redundant functions in neuronal radial migration.

The latter suggests that additional components or redundant circuits that render a higher robustness to alterations are likely to be discovered for the SCN GRN.

To identify cancer-associated chromatin factor alterations that are either synergistic or redundant, we searched for co-occurring and mutually exclusive mutation patterns, respectively (Additional file 5: Table S2).

However, no obvious morphological abnormality was observed in the liver when biochemical alterations such as lipid peroxidation were not detectable, suggesting a redundant or less important physiological role for MnSOD in the liver than previously thought.

In other words, alterations of both CCNA1 and TP53 in HNSCC will be redundant.

Interestingly, MuRF-1 deficient mice exhibit no major alterations in the levels of ubiquitination within the myocardium, suggesting redundant functionality among MuRFs in cardiac muscle [ 157].