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This finding may be explained by redundant actions of PD0332991 and Hsp90 inhibitors: PD0332991 inactivates CDK4 and CDK6, and Hsp90 inhibitors downregulate CDK4 and CDK6.
Although an earlier report from our laboratory revealed that brain abscess pathogenesis was more severe in mice lacking IL-1β, this study did not address the potential redundant actions of IL-1α in the context of CNS S. aureus infection (Kielian et al., 2004).
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But the rest of the movie is distended with a series of wacky vignettes and redundant action, including a superfluous if entertaining and atmospheric scene in which Hemmings finds himself at a secret concert given by the Yardbirds in a basement club off Oxford Street.
Hardcore Gamers Nikola Suprak commented that several of the levels he played through were visually indistinct from one another, before saying that "level after level of redundant action and repetitive encounters ultimately drag the game down".
Juvenile-to-adult growth phase transition and leaf initiation rate are controlled by the redundant action of AtSPL9 and AtSPL15[ 21].
In the reference to the redundant action of SNARE components, the vti11 mutant is mentioned as displaying roundish vacuoles.
Transcription profiles of gene family members can be compared to yield information on their possible redundant action, or to identify members that act alone in specific cell types.
As we have concluded previously, redundant action by other MADS domain proteins may be taking over the function of GRCD1 in disc flowers [ 41].
We cannot rule out that there is redundant action of APC2, for example, in the APC-knockdown cells sufficient for restricting Wnt pathway activation.
Clock Δ19/ Δ mutant mice on the C57BL/6J background lose locomotor activity rhythmicity when housed in constant darkness [ 120, 123], while Clock−/− mice maintain behavioral rhythmicity through the redundant action of NPAS2 in the SCN [ 4, 5, 117].
This is in line with previous reports [ 8, 13] and contradicts to some extend a recent study, showing concerted and partially redundant action of PI3Kγ and PI3Kβ isoforms downstream of GPCR [ 24].
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