Our catalogue (Supplementary Table S2) was rigorously filtered ensuring estimated spectral false positive rates below 1% and minimal redundancy (see Materials and Methods for details).
The SVD algorithm was employed to check this redundancy (See Materials and methods).
We suggest that the benefit of increased robustness in the face of disturbance and VLA increase outweighed the rather minor costs of redundancy in terms of material investment.
Gene duplication can be a major source of innovation in evolution [ 1], providing redundancy and additional genetic material to build upon and differentiate.
This evolution is driven by several forces, among them gene duplication and lateral gene transfer, which are believed to provide raw material for functional redundancy and novelty.
Among the various evolutionary forces driving genome plasticity, gene duplication and lateral gene transfer are believed to provide raw material for functional redundancy and novelty in the development of biological systems in bacteria [ 1].
Genomes were sequenced using Illumina technology with median coverage of 258-fold average nucleotide redundancy (supplementary fig. S1, Supplementary Material online).
This intrinsic redundancy offers potential advantages with FFPE material, as it increases the likelihood of detecting intact and measurable RNA for each gene of interest.
Redundancy there may be due to material constraints that prevent the minimal realization of a network but allow a more complex one.
Duplication of genetic material immediately leads to genetic redundancy, whereby gene copies can subsequently diverge and evolve toward novel or altered functionality [ 35] (Fig. 2C).
