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4) Given the large effect of Wnt4 knockdown, the redundancy argument is not strong.
In accordance with the redundancy argument, we did not observe any developmental defects resulting from mutations in individual BraA.RPL paralogues.
When they combined this UPII-driven expression of Egfr with the activated Hras transgene in a compound transgenic mouse, there was no synergism between the two mutations, strengthening the redundancy argument because both are in the same signal transduction cascade.
b) One assumes that the p-value resulting from loss of Wnt4 alone (using D1), in Figure 7D is not correct, certainly looks that way from the graph, but if somehow this p value is in the e-9 range (rather that about 0.1 or so), then we have a big problem with the redundancy argument.
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Can the argument about redundancy in the discussion be strengthened?
Another argument against the redundancy model is that if a protein-coding gene was genuinely redundant then eventually, as it diverged from its functional paralog, it would accumulate an obvious inactivating mutation.
Interestingly, this possibility agrees with our lysosome count from TEM images (110 lysosomes/cell) and with the argument of natural redundancy we contemplated to explain the discrepancy between the calculated and observed lysosome number estimates.
Readers have to endure not only the absence of direction and analytic argument, but also frequent redundancies and narrative switchbacks.
There's a petition in support of King's staff under threat of redundancy: take a look at the arguments and consider signing.
Similar arguments apply to the redundancy of variables related to vernalisation.
However, there are also several arguments against the general functional redundancy of these ligands.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com