Exact(3)
A synchrony of S-phase with the most reductive stage of YMC may avoid oxidative damage to replicating DNA, thus providing genome protection.
Indeed, in some yeast mutant stains, S-phase was shifted either left- or right-ward of the most reductive stage of YMC, and these strains accumulate a high level of spontaneous mutations [ 21].
In YMC, many biological/metabolic processes are compartmentalized in time, and YMC is characterized by oxidative, reductive/building and reductive/charging phases, which are in synchrony with the yeast cell cycle in that the S-phase overlaps with the most reductive stage of YMC (the early stage of the reductive/building phase) [ 20].
Similar(56)
Split ORFs were first described in the Rickettsia conori genome [ 21], and are postulated to represent genes that are in the first stage of reductive evolution.
It was also found, using superoxide dismutase (SOD), that the first stage undergoing reductive activation according to the mechanism of the redox cycling had the key importance for the metabolic conversion of DOX.
Two Calyptogena clam intracellular obligate symbionts, Ca. Vesicomyosocius okutanii (Vok; C. okutanii symbiont) and Ca. Ruthia magnifica (Rma; C. magnifica symbiont), have small genomes (1.02 and 1.16 Mb, respectively) with low G+C contents (31.6% and 34.0%, respectively) and are thought to be in an ongoing stage of reductive genome evolution (RGE).
Differences in the number of MGEs in the three B. pilosicoli genomes may relate to their different stages of reductive genome evolution.
It indicates that the first stage of DOX reduction by CPR, undergoing reductive activation probably according to the mechanism of the redox cycling, has the key importance for the metabolic conversion of DOX.
Reduction of azo bond and reductive activation of pro-drugs at initial level is a crucial stage in degradation and detoxification mechanisms.
It paints the campaign process as reductive and constraining, so remorselessly stage-managed that it reduces the contenders to a bunch of bad actors.
Just as the actual subject of "Schindler's List" is the oblivious vanity, the temerity — the chutzpah — that it takes to make such a film, the subject of "Detroit" is the fact of Bigelow at work staging horrific events in reductive specificity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com