Your English writing platform
Discover LudwigExact(20)
What might be the physiological significance of the reductive shift of the calcium-depleted ER?
The evidence for specificity is further buttressed by the significant effacement of the reductive shift in cells lacking CRT.
The reductive shift in ER redox poise, observed at physiological ER calcium store depletion, is an unusual exception to a landscape dominated by stability of ER redox balance.
The fluorescent lifetime of the probe declined in thapsigargin-treated HEK 293 T cells, reflecting the reductive shift in the dithiol-disulfide steady state [ 9].
The reductive shift noted upon ER calcium depletion is significantly attenuated but not completely lost in cells lacking CRT, indicating the existence of other contributory factors.
Despite these limitations to our understanding, the mechanism(s) promoting a reductive shift in the calcium depleted ER are defined with considerable specificity.
Similar(40)
Coupling such reductive shifts to PERK-mediated attenuation of protein synthesis would lessen their impact on oxidative folding of newly-synthesized proteins, while promoting the degradation of refuse.
As shown in Figure 8, as v is increased by 2 orders of magnitude, the oxidative and reductive peaks shift from the midpoint position by over 110 mV, and the shape of the peak broadens by ∼50%.
The reductive potential was shifted in a positive direction with increasing PEG chain length (see Figure S4d, Supporting Information), indicating a decrease in the attractive interactions between adjacent chains.
The reductive explanation is that the shift hinges on one thing, which you can hear at its most brilliantly realised on With the Beatles, released in November: British musicians attempting to copy black Americans and stumbling on a sound entirely of their own – raw, swaggering, exuberant – in the process.
In reductive terms, the band has shifted away again from solid riffs and toward diffuse texture, as it did in 2000, on "Kid A" (Capitol).
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com