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Despite a significant reduction in SBP and DBP with the two antihypertensive drugs, there were no beneficial renal histological changes compared with placebo, nor were there any reductions the development of microalbuminuria (actually being higher among patients taking the A2A) or in the decline in glomerular filtration rate.
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(5) Towards tsunami disaster reduction, the development of seismology and tsunami science can be implemented as tsunami early warning systems, tsunami hazard maps, and probabilistic tsunami hazard assessments.
In vivo, although MU showed only a mild inhibitory effect on the growth of the primary tumour, it markedly inhibited (75% reduction) the development of lung metastasis.
While the development of more severe toxicities led to a dose delay or dose reduction, the development of individual grade 1 toxicities alone did not mandate any dose modification.
However, while a national screening programme may follow if the trials do provide evidence of mortality reduction, the development and implementation of such a programme is likely to take several years.
Improvements in tolerability and safety have been achieved, without compromises in effectiveness, primarily via hormone dosage reductions and the development of several new progestins.
Obama, meanwhile, has made some in-roads on greenhouse gas reductions, including the development of tough new fuel efficiency standards for vehicles and a proposal for new limits on power plant emissions.
Prospective randomised controlled trials with cardiovascular disease as the primary end point have shown, from secondary analyses, reductions in the development of colorectal cancer and death from malignancy.
The entry of many manufacturers producing quality-assured generic ARVs, dramatic price reductions, and the development of innovative FDCs all indicate a largely decentralized and efficient market by conventional measures.
This study suggests that acarbose treatment was associated with a reduction in hypertension and cardiovascular disease: this treatment resulted in a 25% relative risk reduction in the development of T2DM, in a 34% risk reduction in the development of new cases of hypertension, and in a 49% risk reduction in cardiovascular events.
Therefore, it is uncertain whether the observed reduction in the development of severe sepsis and/or septic shock is associated with reductions in the SOFA score over time.
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