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While progressive changes in capillary morphology and function may cause reductions in nerve function and even nerve damage, these mechanisms fail to explain the mechanical hyperalgesia and tactile allodynia (sensation of pain in response to otherwise non-painful stimuli) experienced by nearly half of patients with diabetic neuropathy [ 3].
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Some reduction in nerve function occurred between 1 and 2 mm away from the nerve.
Patients with a congenital etiology showed a greater reduction in nerve function than those with growth disturbance (chi-squared, p = 0.03) (Table 3).
Improvement in nerve function was measured as a mean score using graded nylon filaments (score per nerve) and the Medical Research Council MRCC) scale (0 5 score per nerve).
Axonal atrophy is more common observed (Verdu et al 2000) while nerve conduction and endoneural blood flow are reduced with advancing age contributing to a reduction in peripheral nerve function (Verdu et al 2000).
This subsequently contributes to reductions in nerve thresholds at nociceptive terminals, increases in sensitivity, and amplification of the excitability of the peripheral afferent nerve fibers [32].
The inhibitory effects of cocaine on immature brain could not be attributed to localized actions at the nerve terminal itself (blockade of reuptake, autoreceptor activation, local anesthesia), but instead are likely to represent reductions in nerve impulse activity.
This subsequently contributes to reductions in nerve thresholds at nociceptive terminals, increases in sensitivity, and amplification of the excitability of the peripheral afferent nerve fibers [ 32].
(3) In most cases, improvement in peripheral nerve function after excision of schwannoma is achieved.
56 58 Many of these effects are likely to be mediated through changes in vagal nerve function.
Besides a general reduction in nerve fibre density, nerve fibres immunoreactive for nNOS or VIP or both were increased.
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