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Two variants containing combinations of three (3-MUT: M74A, M141T, S174Q) or four (4-MUT: M74A, K86Q, M141T, S174Q) active mutations showed further reductions in activity.
This observation is the foundation for Williams' theory of antagonistic pleiotropy [ 191], which predicts that stress response mechanisms and other pathways that benefit the organism would be activated early in life at levels ensuring optimal reproductive fitness, but reductions in activity at post-reproductive ages ("gene expression drift") would not be selected against.
Low frequency (once per second) TMS has been shown to induce small, sustained reductions in activity in the part the brain that has been stimulated.
Furthermore, we observed reductions in activity in the basolateral amygdala, a key regulator of the brain's reward system.
Furthermore, repetition-related reductions in activity in the left inferior frontal cortex for possible objects correlated with repetition-related facilitation in reaction time across both young and elder subjects.
Reductions in crime, reductions in arrests, reductions in activity in open-air drug markets, reductions in fatal overdose, not to mention promotion of social integration, including considerable improvements in participants' housing situation and fitness for work.
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Pulmonary function in patients with ≥10 pack-years of smoking and diabetes is reduced, and this decrease is associated with significant reductions in activity-related quality of life and exercise capacity.
Significant reduction in activity was also shown after treatments on d1 with the active sonic toothbrush.
The ribozyme is also active in molar concentrations of NaCl, but with a 3000-fold reductinn in activity.
"There was certainly a reduction in activity today," he said.
As expected, light exposure caused a significant reduction in activity, T b and HR.
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