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TCM provided significantly greater short-term (8-week) relief than SC (CFP reduction difference, −.60 [standard deviation of the estimate.26], P =.020) and greater reduction in interference with social activities (−.81 [standard deviation of the estimate.33], P =.016).

In the placebo group, 33 dose-increases and 16 dose-reductions (difference of 17) were recorded and in cholecalciferol group 29 dose-increases and 23 dose-reductions (difference of 6) were observed.

The surrogate threshold effect (STE) is the minimum by-arm blood pressure reduction difference that predicts a by-arm stroke reduction benefit.

Adding the fatty food requirement to a 12-tablet daily regimen resulted in a statistically significant utility reduction (difference = 0.04; P < 0.001) (Table  4).

Other statistics reported are the R-squared at the trial level (Rtrial-level) of the weighted errors-in-variables regression model as well as the coefficient (slope) of the blood pressure reduction difference.

The first was the relative reduction of the annual number of bed days between the post- and pre-vaccination periods, and the second was the absolute reduction (difference) (95% CI) of the number of bed days, based on a vaccine probe approach [ 21].

Hcys: homocysteine; MMA: methylmalonic acid; NNT: number needed to treat; SD: standard deviation; RΔ%: relative reduction difference towards the healthy population's mean value BF, PV, LH, BB, GA, OB, TB, and FV all declare the absence of any financial or non-financial competing interests.

However, for large AF reduction differences (−30.1% versus −2.8%) between groups of subjects in the same exercise program (objective 2), only creatinine and VO2 max were different.

For the two time-to-event secondary outcomes (time needed to achieve satisfactory analgaesia and 50% pain reduction), differences between the two groups will be tested using a log-rank test.

To aid interpretation of the change in variables following pain reduction, differences in kinematics were sign normalised so increases in the variable (i.e. greater ROM or greater velocity/acceleration) were assigned positive values and decreases in the variable were assigned negative values.

Based on the X-ray structure of A. fulgidus, the large reduction potential difference of the two clusters was explained by their distinctly different surrounding protein matrix (see Fig. 5 panel A).

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