The 1.7 relative risk of strokes in hypertensive patients [ 19] translates into a potential 41.2% reduction of strokes and stroke sequlae in successfully treated hypertensive cases.
18 Nevertheless, a reduction in stroke risk was not observed in the Vitamin Intervention for Stroke Prevention (VISP) trial, in which stroke was the primary end point.
Combinations of the antioxidants had no effect either, except for a slight reduction in stroke among those taking both vitamins C and E together.
"As a result, the decrease in salt intake would have played an important role in the reduction of stroke and ischaemic heart disease mortality during this period," say the authors.
The benefit is primarily a result of the reduction in stroke and bleeding events.
Rewarming from hypothermia is often complicated by cardiac dysfunction, characterized by substantial reduction in stroke volume.
Therefore, even a small reduction in stroke recurrence risk or severity has the potential to yield significant economic benefits.
Despite good evidence for the reduction of stroke risk with anticoagulant therapy, there remains a significant undertreatment.
Conversely, dietary potassium intake attenuates these effects, showing a linkage to reduction in stroke rates and cardiovascular disease risk.
The study has been designed to provide 90% statistical power (with 2-sided α =.05) to detect a 13% or greater relative risk reduction for stroke.
