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Dose reduction schema for nab-paclitaxel and S-1.
Since we had decided to include in our trial anthracycline- and taxane-pretreated patients, we planned a dose reduction schema for haematologic toxicity for paclitaxel.
Actually, we observed only grade 1 and 2 haematologic toxicity in a few patients, and we think that our dose reduction schema is excessive and unnecessary.
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In a subsequent phase 2 study in previously treated patients with HCC and Child-Pugh A cirrhosis, the tivantinib dose was reduced to 240 mg BID and a modified dose-reduction schema was implemented because of grade 3 or greater neutropaenia (Santoro et al, 2012).
In Figure 4, schema summarising the reduction of DOX by CPR under various experimental conditions studied in the work are presented.
They consider reconstruction as the central retrieval process of schema theory, and reduction of the amount of information as an important element, but recognize that memory representation is far richer and detailed than schema theory would suggest.
In general, results suggest that intervention of depressed women may need to target the changing of DR schemas, NESs and reduction of EA.
Our experiments demonstrate that both fixed and elastic schemas achieve significant overhead reduction without compromising on accuracy.
By addressing these core components of the vulnerability schema underlying the fear, reductions in fear should occur more rapidly and be longer lasting.
Using our schema the sample receives a typical reduction of probe (5x) and pump (15x) beam intensity for the same input power compared to previously reported phonon detection methods22,32.
It seems reasonable to expect something like philosophical reductions to be possible in those situations where Schema R holds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com